منابع مشابه
A novel type of familial hypercholesterolemia: double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene.
BACKGROUND Autosomal recessive hypercholesterolemia (ARH) is an extremely rare inherited hypercholesterolemia, the cause of which is mutations in low-density lipoprotein (LDL) receptor adaptor protein 1 (LDLRAP1) gene. METHODS A total of 146 heterozygous familial hypercholesterolemic (FH) patients with a mutation in LDLR gene were screened for genes encoding proprotein convertase subtilisin/k...
متن کاملLDL stimulates mitogen-activated protein kinase phosphatase-1 expression, independent of LDL receptors, in vascular smooth muscle cells.
Low density lipoprotein (LDL) is a well-established risk factor for atherosclerosis, stimulating vascular smooth muscle cell (SMC) differentiation and proliferation, but the signal transduction pathways between LDL stimulation and cell proliferation are poorly understood. Because mitogen-activated protein kinases (MAPKs) play a crucial role in mediating cell growth, we studied the effect of LDL...
متن کاملPredicting Protein - Protein Interactions for Integrins and an LDL Receptor
Title of Presentation Name of Student Author, Co-Investigator, Co-Investigator Name of mentor, rank of mentor, department of mentor Student presenter names are in bold. Non-presenting co-investigators are not in bold All investigators are assumed to be from UMBC unless otherwise noted. Mentor information is shown below author information, in roman type. If the mentor is not from UMBC, an instit...
متن کاملEffect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer
Low-density lipoprotein (LDL) receptors are overexpressed in most neoplastic cell lines and provide a mechanism for the internalization and concentration of drug-laden nanoemulsions that bind to these receptors. The aim of the present study was to determine whether the administration of standard chemotherapeutic schemes can alter the expression of LDL and LDL receptor-related protein 1 (LRP-1) ...
متن کاملHuman coronary smooth muscle cells internalize versican-modified LDL through LDL receptor-related protein and LDL receptors.
Versican-like proteoglycans are the main component of the intimal extracellular matrix interacting with low density lipoprotein (LDL). The aim of this study has been to investigate the receptors involved in versican-modified LDL uptake by human vascular smooth muscle cells (VSMCs). We have found that versican-LDL interaction leads to the following: (1) monomeric LDL particles that are similar i...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2014
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2013.08.029